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{Disarmed} New Protein Spotlight Comic Strip issue: Silent pain
by Protein Spotlight 04 May '20

04 May '20

((( New Protein Spotlight Comic Strip issue: Silent pain ))) May 2020 ------------------------------------------------------------------------ Is there really a point to pain? Yes, argue most. Pain warns you that something is not right. It teaches children not to put their hands on a hot plate because they know heat hurts. It urges you to consult your doctor when pain persists in any part of your body. Yes, but what about pain that accompanies something which has already been diagnosed? What about the persistent pain that frequently escorts chronic conditions, such as a sore back or cancer? Who can see the good in that kind of pain? Though there may be instances when it seems superfluous and even cruel, the sensation of pain is more necessary than it is not. It is a clear indicator that there is something wrong, and that it needs to be seen to. In the absence of pain, no alert signals are given off - which could ultimately put your life in danger. It is a complex sensation with many a meaning and many a pathway. One particular pathway was discovered when members of a family were incapable of feeling pain - a singular and rare condition due to the loss of function of a protein known as SCN9A or Nav1.7. Link to this comic strip: https://www.proteinspotlight.org/back_issues/102/comic/ You'll find the original article at: https://www.proteinspotlight.org/back_issues/102/ If you wish to unsubscribe, you may do so here: https://www.proteinspotlight.org/unsubscribe/

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{Disarmed} New Protein Spotlight Comic Strip issue: Silent pain
by Protein Spotlight 04 May '20

04 May '20

((( New Protein Spotlight Comic Strip issue: Silent pain ))) May 2020 ------------------------------------------------------------------------ Is there really a point to pain? Yes, argue most. Pain warns you that something is not right. It teaches children not to put their hands on a hot plate because they know heat hurts. It urges you to consult your doctor when pain persists in any part of your body. Yes, but what about pain that accompanies something which has already been diagnosed? What about the persistent pain that frequently escorts chronic conditions, such as a sore back or cancer? Who can see the good in that kind of pain? Though there may be instances when it seems superfluous and even cruel, the sensation of pain is more necessary than it is not. It is a clear indicator that there is something wrong, and that it needs to be seen to. In the absence of pain, no alert signals are given off - which could ultimately put your life in danger. It is a complex sensation with many a meaning and many a pathway. One particular pathway was discovered when members of a family were incapable of feeling pain - a singular and rare condition due to the loss of function of a protein known as SCN9A or Nav1.7. Link to this comic strip: https://www.proteinspotlight.org/back_issues/102/comic/ You'll find the original article at: https://www.proteinspotlight.org/back_issues/102/ If you wish to unsubscribe, you may do so here: https://www.proteinspotlight.org/unsubscribe/

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Latest Protein Spotlight issue: dropping barriers
by Protein Spotlight 09 Jan '20

09 Jan '20

((( Latest Protein Spotlight issue: dropping barriers ))) January 2020 ------------------------------------------------------------------------ Blood. It is deep red, liquid and essential to life, and courses through us from the very early stages of our development to our final gasp. It cannot have taken long for our ancestors to make the link between blood and life. They will have seen the rich red fluid seep from wounds alongside the lifeless bodies of animals they had just hunted down, and understood that the same fluid flows through their own bodies. Blood is indeed a tissue (albeit liquid) of vital importance, composed of myriads of crucial cells and nutrients, which is why - when lost - it is transfused. There is a snag however: no two bloods are identical. But all human bloods can be sorted into well-defined groups of which the most representative are the A, B, AB and O blood groups. The O blood group can be transfused to everyone, while the other blood groups cannot. This is why scientists have been searching for ways, literally, to shift A, B and AB blood types to the 'universal' O blood type - which could resolve the problem of insufficient stocks in blood banks. There have been several attempts, none of which conclusive. One more promising attempt involves bacteria from our gut microbiome, and two enzymes: a D-galactosamine deacetylase and a D-galactosamine galactosaminidase. Read more: http://www.proteinspotlight.org If you would like to make a direct link to this issue, please use the following link: http://www.proteinspotlight.org/back_issues/220/ If you wish to unsubscribe, you may do so here: http://www.proteinspotlight.org/unsubscribe/

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Latest Protein Spotlight issue: sting
by Protein Spotlight 09 Jan '20

09 Jan '20

((( Latest Protein Spotlight issue: sting ))) January 2020 ------------------------------------------------------------------------ Venomé hasà a «language of its own». The recurring message is not a nice one, and usually expresses one thing: back off. Certain animals use venom - a cocktail of molecules - to ward off predators or, at the very least, to divert oncoming danger. We all know what a wasp's sting is like and many of us may have felt the sting of a jellyfish, or perhaps even the bite of a snake. It is a painful experience. To what end? The reason is twofold: one, we at once recoil from the animal that has just caused pain and two, our body is instantly told where it hurts. Concomitantly, the animal takes flight while our body attends to our wound. The feeling of pain itself is caused by the opening and closing of minute channels that riddle the membranes of our nerve cells just under our skin. This gives rise to pain signals that originate at the location of the sting, or bite, and are relayed to our brain. Understanding how pain occurs on the molecular plane helps scientists find ways of designing pain relievers. However, more often than not, pain is usually accompanied by swelling which has a protective role. So we face a conundrum: how do you relieve pain while preserving inflammation? One particular scorpion toxin, the Black Rock scorpion toxin known as the wasabi receptor toxin or WaTx, may well provide an answer. Read more: http://www.proteinspotlight.org If you would like to make a direct link to this issue, please use the following link: http://www.proteinspotlight.org/back_issues/219/ If you wish to unsubscribe, you may do so here: http://www.proteinspotlight.org/unsubscribe/

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test2
by Karin Sonesson 12 Dec '19

12 Dec '19

dsafsdf -- *Karin Sonesson* System Administrator *SIB | Swiss Institute of Bioinformatics* Karin.Sonesson(a)sib.swiss - www.sib.swiss The information in this e-mail, and those ensuing, is confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, please destroy this message and notify the sender immediately.

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test
by Karin Sonesson 12 Dec '19

12 Dec '19

sdfasdf -- *Karin Sonesson* System Administrator *SIB | Swiss Institute of Bioinformatics* Karin.Sonesson(a)sib.swiss - www.sib.swiss The information in this e-mail, and those ensuing, is confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, please destroy this message and notify the sender immediately.

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test
by Karin Sonesson 05 Dec '19

05 Dec '19

-- *Karin Sonesson* System Administrator *SIB | Swiss Institute of Bioinformatics* Karin.Sonesson(a)sib.swiss - www.sib.swiss The information in this e-mail, and those ensuing, is confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, please destroy this message and notify the sender immediately.

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test
by Karin Sonesson 03 Dec '19

03 Dec '19

-- *Karin Sonesson* System Administrator *SIB | Swiss Institute of Bioinformatics* Karin.Sonesson(a)sib.swiss - www.sib.swiss The information in this e-mail, and those ensuing, is confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, please destroy this message and notify the sender immediately.

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testg
by isb sib 03 Jul '19

03 Jul '19

testg

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test
by Karin Sonesson 03 Jul '19

03 Jul '19

test -- *Karin Sonesson* System Administrator *SIB | Swiss Institute of Bioinformatics* Karin.Sonesson(a)sib.swiss - www.sib.swiss The information in this e-mail, and those ensuing, is confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, please destroy this message and notify the sender immediately.

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