Dear all, Another seminar in our series of statistics talks for people interested in quantitative methods in biology and medicine will take place on Monday 16 April 2018 at 15:00, in the Salle Delachaux (Biopôle 2, first floor, Route de la Corniche 10, 1010 Lausanne, M2: Vennes). The speaker will be Prof. Tianxi Cai from the Department of Biostatistics at the Harvard School of Public Health. Title: Enabling Imprecise EHR Data for Precision Medicine Abstract: While clinical trials remain a critical source for studying disease risk, progression and treatment response, they have limitations including the generalizability of the study findings to the real world and the limited ability to test broader hypotheses. In recent years, due to the increasing adoption of electronic health records (EHR) and the linkage of EHR with specimen bio-repositories, large integrated EHR datasets now exist as a new source for translational research. These datasets open new opportunities for deriving real-word, data-driven prediction models of disease risk and progression as well as unbiased investigation of shared genetic etiology of multiple phenotypes. Yet, they also bring methodological challenges. For example, obtaining validated phenotype information, such as presence of a disease condition and treatment response, is a major bottleneck in EHR research, as it requires laborious medical record review. A valuable type of EHR data is narrative free-text data. Extracting accurate yet concise information from the narrative data via natural language processing is also challenging. In this talk, I'll discuss various statistical and informatics methods that illustrate both opportunities and challenges when using EHR data for translational research. These methods will be illustrated using EHR data from Partner's Healthcare. Hope to see you there! Valentin (for the organizers: Zoltán Kutalik, Valentin Rousson, Frédéric Schütz) CHUV centre hospitalier universitaire vaudois Valentin ROUSSON - Professeur associé, mathematicien/statisticien Département universitaire de medecine et santé communautaires (DUMSC) Médecine sociale et préventive (IUMSP) Biostatistique et méthodes quantitatives BIO 2/2ème/103 Rte de la Corniche 10, CH - 1010 Lausanne +41 (0)21 314 73 28 TEL Valentin.Rousson@chuv.chmailto:Valentin.Rousson@chuv.ch www.chuv.chhttp://www.chuv.ch/