Dear all,

The next seminar in our series of statistics talks for people interested in quantitative methods in biology and medicine will take place on this Thursday 8 June 2017 at 11:00, in the Salle Delachaux (Biopôle 2, first floor, Route de la Corniche 10, 1010 Lausanne, M2: Vennes).

The speaker will be Dr. Aaron McDaid (group of Zoltán Kutalik, IUMSP, University Hospital Lausanne).

Title: Bayesian association scan reveals loci associated with human lifespan and linked biomarkers

Abstract: The enormous variations in human lifespan are in part due to a myriad of sequence variants, only a few of which have been revealed to date. Since many life-shortening events are related to diseases, we developed a Mendelian randomization-based method combining 58 disease-related GWA studies to derive longevity priors for all HapMap SNPs. A Bayesian association scan, informed by these priors, for parental age of death in the UK Biobank study (n=116,279) revealed 16 independent SNPs with significant Bayes factor at a 5% false discovery rate (FDR). Eleven of them replicate (5% FDR) in five independent longevity studies combined; all but three are depleted of the life-shortening alleles in older Biobank participants. Further analysis revealed that brain expression levels of nearby genes (RBM6, SULT1A1, CHRNA5) might be causally implicated in longevity. Gene-expression and caloric restriction experiments in model organisms confirm the conserved role for RBM6 and SULT1A1 in modulating lifespan.

Hope to see you there!

Valentin
(for the organizers: Zoltán Kutalik, Valentin Rousson, Frédéric Schütz)