Dear all,

Another seminar in our series of statistics talks for people interested in quantitative methods in biology and medicine will take place on Tuesday 15 May 2018 at 11:00, in the Salle Delachaux (Biopôle 2, first floor, Route de la Corniche 10, 1010 Lausanne, M2: Vennes).

The speaker will be Aziz Chaouch from the Institute of Social and Preventive Medicine, University of Lausanne.

Title: Meta-analysis of heterogeneous predictive models based on Monte Carlo simulations and the concept of a meta-model

Abstract: Predictive models are being increasingly used in clinical practice e.g. to predict future drug plasma concentrations in subpopulations of patients as a function of the dosage regimen. When different studies developed predictive models for the same outcome, one would like to combine evidence from these models to optimize the quality of predictions. One problem is that the different studies may have used different predictive models with e.g. different sets of predictors. We shall present a simulation approach to allow a meta-analysis of such heterogeneous predictive models. The method postulates a hypothetic model (called the meta-model) which supposedly approximates the data generating mechanism common to all studies. By generating pseudo-observations from the meta-model and refitting the possibly misspecified models to these pseudo-data, it is possible to estimate meta-model parameters using an iterative procedure. Statistical properties of the method will be presented in the context of linear and linear mixed models.

This is a joint work with Thierry Buclin and Valentin Rousson

Hope to see you there!

Valentin
(for the organizers: Zoltán Kutalik, Valentin Rousson, Frédéric Schütz)

CHUV
centre hospitalier universitaire vaudois

Valentin ROUSSON - Professeur associé, mathematicien/statisticien
Département universitaire de medecine et santé communautaires (DUMSC)
Médecine sociale et préventive (IUMSP)
Biostatistique et méthodes quantitatives

BIO 2/2ème/103
Rte de la Corniche 10, CH - 1010 Lausanne

+41 (0)21 314 73 28  TEL
Valentin.Rousson@chuv.ch
www.chuv.ch