November 2017 - statslausanne

This afternoon at 15:30: Presentation by Stephen Senn on Precision Medicine
by Frédéric Schütz 22 Nov '17

22 Nov '17

Dear all, quick reminder that this afternoon, at 15:30, the SIB and the CIG will host statistician Stephen Senn (Head of Competence Center for Methodology and Statistics (CCMS), Luxembourg Institute of Health) who will talk about: Is Precision Medicine Terminally Ill? The presentation will take place in Auditoire A of the Génopode Building, on the Dorigny campus of the University of Lausanne. The presentation will be broadcast live at https://collab.switch.ch/sib-cbss/ It will also be available later on the SIB Youtube channel at https://www.youtube.com/channel/UCPo4ED_WAKjwQ878cca6_oQ Hope to see you there ! Frédéric Abstract: For at least twenty years we have been promised that a revolution in medical care, based mainly on genomics, but also on various other 'omics', is imminent. Precise diagnosis will be matched by tailor-made medicine and put an end to mass solutions doled out to crudely assembled disease groups. In those 20 years, the relevant vocabulary has been reinvented several times moving from personalized, to precision to high-definition medicine. However, despite some notable successes the theranostic revolution has not taken place and the reality continues to fall far short of the promise. I shall argue that one reason is that clinical trials are regularly misunderstood and all too frequently badly analysed. In particular, an obsession with numbers needed to treat based on arbitrary dichotomies has exaggerated the extent to which patients differ in response and hence the scope for personalising therapies. I shall suggest that smarter design and analysis of trial is needed and that it is quite probable that the scope for personalised medicine is less than commonly supposed. The main task for drug development will remain finding treatments that are good on average. ---

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Statistical forum on Wednesday 22 November 15:30
by Frédéric Schütz 08 Nov '17

08 Nov '17

Dear all, The next seminar in our series of statistics talks for people interested in quantitative methods in biology and medicine will take place on Wednesday 22 November 2017, 15:30, in Auditoire A of the Génopode Building (Dorigny campus). The speaker will be Stephen Senn (Head of Competence Center for Methodology and Statistics (CCMS), Luxembourg Institute of Health) Title: Is Precision Medicine Terminally Ill? For at least twenty years we have been promised that a revolution in medical care, based mainly on genomics, but also on various other 'omics', is imminent. Precise diagnosis will be matched by tailor-made medicine and put an end to mass solutions doled out to crudely assembled disease groups. In those 20 years, the relevant vocabulary has been reinvented several times moving from personalized, to precision to high-definition medicine. However, despite some notable successes the theranostic revolution has not taken place and the reality continues to fall far short of the promise. I shall argue that one reason is that clinical trials are regularly misunderstood and all too frequently badly analysed. In particular, an obsession with numbers needed to treat based on arbitrary dichotomies has exaggerated the extent to which patients differ in response and hence the scope for personalising therapies. I shall suggest that smarter design and analysis of trial is needed and that it is quite probable that the scope for personalised medicine is less than commonly supposed. The main task for drug development will remain finding treatments that are good on average. --- Hope to see you there! Frédéric

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Statistical forum on Friday October 13 at 11:00
by Rousson Valentin 02 Nov '17

02 Nov '17

Dear all, The next seminar in our series of statistics talks for people interested in quantitative methods in biology and medicine will take place on Friday 13 October 2017 at 11:00, in the Salle Delachaux (Biopôle 2, first floor, Route de la Corniche 10, 1010 Lausanne, M2: Vennes). The speaker will be Prof. Eva Cantoni (Research Center for Statistics and Geneva School of Economics and Management, University of Geneva). Titre: A random-effects hurdle model for predicting bycatch of endangered marine species Abstract: Understanding and reducing the incidence of accidental bycatch, particularly for vulnerable species such as sharks, is a major challenge for contemporary fisheries management worldwide. Bycatch data, most often collected by at-sea observers during fishing trips, are clustered by trip and/or vessel and typically involve a large number of zero counts and very few positive counts. Though hurdle models are very popular for count data with excess zeros, models for clustered forms have received far less attention. Here we present a novel random-effects hurdle model for bycatch data that makes available accurate estimates of bycatch probabilities as well as other cluster-specific targets. These are essential for informing conservation and management decisions as well as for identifying bycatch hotspots, often considered the first step in attempting to protect endangered marine species. We validate our methodology through simulation and use it to analyse bycatch data on critically endangered hammerhead sharks from the U.S. National Marine Fisheries Service Pelagic Observer Program. Hope to see you there! Valentin (for the organizers: Zoltán Kutalik, Valentin Rousson, Frédéric Schütz) CHUV centre hospitalier universitaire vaudois Valentin ROUSSON - Professeur associé, mathematicien/statisticien Département universitaire de medecine et santé communautaires (DUMSC) Médecine sociale et préventive (IUMSP) Biostatistique et méthodes quantitatives BIO 2/2ème/103 Rte de la Corniche 10, CH - 1010 Lausanne +41 (0)21 314 73 28 TEL Valentin.Rousson(a)chuv.ch<mailto:Valentin.Rousson@chuv.ch> www.chuv.ch<http://www.chuv.ch/>

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