Dear all,
The next seminar in our series of statistics talks for people interested
in quantitative methods in biology and medicine will take place on
Thursday 13 June 2013 at 11h00 in the Salle Delachaux
(Biopôle 2, premier étage, Route de la Corniche 10, Lausanne, M2: Vennes).
The speaker will be Michael Amiguet from the IUMSP and University Hospital
Lausanne, who will talk about
"Weighted Likelihood Negative Binomial Regression"
The abstract is enclosed. Hope to see you there !
Valentin
(for the organizers: Jérôme Goudet, Valentin Rousson, Frédéric Schütz)
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Dear all,
You might be interested (and are very welcome!) to come in the following seminar given by Dr. Simon Wandel (Cogitars GbbH) visiting the IUMSP on this Thursday 6 june 2013 at 14h00 in the Salle Delachaux (Biopôle 2, premier étage, Route de la Corniche 10, Lausanne, M2: Vennes).
Title: Fully Bayesian trials: an appetizer
Abstract: In the past ten years, the potential of fully Bayesian trials has been recognized by leading Pharmaceutical companies1, regulatory bodies (such as FDA2) and other institutions concerned with all types of research. However, there is still very limited understanding of the clear advantages which Bayesian trials have to offer. This is especially true for situations where traditional concepts such as power do not provide an adequate approach to study design.This talk will start with a short introduction to Bayesian thinking3 followed by real-world examples of fully Bayesian trials. An emphasis will be put on cases where Bayesian trials release their full potential: dealing with parameter uncertainty4, evidence synthesis5, and prediction. In order to actively engage the audience, a real world problem will be posed and discussed at the end of the talk.
References
1. Kakizume, T. Novartis: Challenging to Accelerate Oncology New Drug Development. http://atdd- frm.umin.jp/slide/11/kakizume.pdf accessed on April 11, 2013.
2. FDA - CDRH. Guidance for Industry and FDA Staff Guidance for the Use of Bayesian Statistics in Medical Device Clinical Trials. http://www.fda.gov/downloads/MedicalDevices/DeviceRegulationandGuidance/Gui… accessed on April 25, 2013.
3. Spiegelhalter, DJ, Abrams, K and Myles, J. Bayesian Approaches to Clinical Trials and Health-Care Evaluation. Wiley.
4. Joseph, L, Gyorkos, T and Coupal, L. Bayesian Estimation of Disease Prevalence and the Parameters of Diagnostic Tests in the Absence of a Gld Standard. AJE 141, 1991.
5. Schmidli H, Wandel S, Neuenschwander B. The network meta-analytic -predictive approach to non-inferiority trials. Stat Meth in Med Res, 2011.
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Valentin Rousson
Unité de Statistique
Institut Universitaire de Médecine Sociale et Préventive
Centre Hospitalier Universitaire et Université de Lausanne
Biopôle 2
Route de la Corniche 10
CH-1010 Lausanne
Tél : ++41 (021) 314 73 28
Fax : ++41 (021) 314 73 73
Email: Valentin.Rousson(a)chuv.ch<mailto:Valentin.Rousson@chuv.ch>
